Iodothyronine Levels in the Human Developing Brain: Major Regulatory Roles of Iodothyronine Deiodinases in Different Areas
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چکیده
منابع مشابه
Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas.
Thyroid hormones are required for human brain development, but data on local regulation are limited. We describe the ontogenic changes in T(4), T(3), and rT(3) and in the activities of the types I, II, and III iodothyronine deiodinases (D1, D2, and D3) in different brain regions in normal fetuses (13-20 wk postmenstrual age) and premature infants (24-42 wk postmenstrual age). D1 activity was un...
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The role of the deiodinases D1, D2, and D3 in the tissue-specific and time-dependent regulation of thyroid hormone bioactivity during fetal development has been investigated in animals but little is known about the ontogeny of these enzymes in humans. We analyzed D1, D2, and D3 activities in liver microsomes from 10 fetuses of 15-20 weeks gestation and from 8 apparently healthy adult tissue tra...
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متن کاملExpression profiles of the three iodothyronine deiodinases, D1, D2, and D3, in the developing rat.
Thyroid hormone (TH) is essential for normal development in vertebrate species. Although the mechanisms by which TH regulates developmental processes are not fully understood, intracellular T3 levels are likely to be a critical aspect of the process. Furthermore, as different tissues and organs have specific temporal patterns of development, their T3 requirements may vary widely. Differential r...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2004
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2003-031832